Biological Sciences Program

The Biological Sciences (BS) Program is designed for researchers and professionals with interests in the biological processes that underlie aging. Symposia and poster sessions will address the aging process at the molecular, cellular, and organismal level, as well as the specific disease conditions that are related to, or that accompany, the aging process.  Organized by the GSA Biological Sciences Section.

Experience five days of learning and training that include:

2019 Biological Sciences Program 

Wednesday, November 13

8 a.m. to 12 p.m. • No Fee (Separate Registration Required)
Pre-Conference Workshop
One Health for Healthy Aging: How Companion Animals Can Help Us Solve Aging
Speakers: Kate Creevy, Texas A&M University; Matt Kaeberlein, University of Washington; Natasha Olby, NC State; Daria Fleyshman Vaika; Daniel Promislow, University of Washington
Companion dogs age much like we do, but they do so at an accelerated rate. The "One Health for Healthy Aging" pre-conference workshop will explore how companion dogs are informing us about mechanisms of biological aging and potential interventions to delay age-related declines in function and disease.
Supported by the University of Washington Nathan Shock Center.

12:30 to 2 p.m.
Expanding the Network: Non-Traditional Organismal Models in Geroscience

  • Conservation of Integrative Physiological Aging Mechanisms Across Primates, Alan Cohen, Tina W. Wey, Gabriel Dansereau, Emy Roberge, Véronique Legault, Marie Brunet, Joseph W. Kemnitz, Luigi Ferrucci
  • Mechanisms of Longevity: Lessons from Long-Lived Mammals, Vera Gorbunova
  • Genome-Wide Relaxation of Selective Contraints Underlies the Evolution of Short Life Span in African Killifishes, Dario Riccardo Valenzano, Rongfeng Cui  
  • Marmoset Monkeys as a Model of Aging, Corinna Ross

2:30 to 4 p.m.
DNA Methylation: Cause or Consequence of Aging?

    • A Functional Epigenetic Clock for Rats, Morgan Levine, Ross McDevitt, Luigi Ferrucci, Rafael deCabo
    • Longitudinal Trajectories of Epigenetic Clocks in Humans and Effects of Medication Use, Sara Haag
    • Epigenetic Predictors of Lifespan and Health Span, Ake Lu, Steve Horvath
    • Robust Biomarkers of Aging and Their Biological Origin, Dimitriy Podoloskiy, Vadim Gladyshev

 4:30 to 6 p.m.
Probing the Complex Interactions Between Diet, Disease, and Aging

    • Novel Methionine-Related Interventions that Confer Healthspan Benefits to Yeast and Rodents, Jay Johnson, Jason D. Plummer, Spike D. Postnikoff,  Jessica K. Tyler
    • Metabolic Integrity - A Factor in Aging and a Player in the Mechanisms of CR, Rozalyn Anderson 
    • A Mediterranean Diet Intervention Alters Age-Associated Physiology in a Novel Non-Human Primate Model, Noah Snyder-Mackler, Carol Shively, Corbin Johnson, Kristopfer Michalson, Susan Appt, Daniel Belsky, Thomas Register
    • A Screen of Wild-Derived Fly Strains reveals CG34351 as a Regulator Toxic Effects of a Rich Diet, Rachel Brem, Kenneth A. Wilson, Jennifer N. Beck, Christopher S. Nelson, Pankaj Kapahi

6 to 8 p.m.
President's Welcome Reception and Exhibit Hall Opening
BS Poster Session (Face-to-Face Time with Presenters 6 to 7 pm)

Thursday, November 14

8 to 9:30 a.m.
Systems Biology of Aging

  • Systems Level Understanding of Aging, Vyacheslav Labunsky
  • How Many Molecular Mechanisms Must be Altered Simultaneously to Slow Aging and Extend Lifespan, Nicholas Stroustrup
  • Waddington's Landscape of Cell Aging, Nan Hao, Yang Li, Yanfei Jiang, Julie Paxman, Richard O’Laughlin, Lorraine Pillus, Lev Tsimring, Jeff Hasty
  • Disruption of CpG Island-Mediated Chromatin Architecture and Transcriptional Homeostasis During Aging, Samuel Beck, Junyeong Lee

10 to 11:30 a.m.
President’s Opening Plenary Session

12 to 1:30 p.m.
Biological Sciences Presidential Symposium: Expanding the Geroscience Network
Chair:
Matt Kaeberlein

  • Omics in Aging Research: From Biomarkers to Systems Biology, Daniel Promislow
  • Heterogeneity of Aging in Human Populations, Jing-dong (Jackie) Han
  • Epigenetic and metabolic regulation of aging, Anne Brunet

5 to 6:30 p.m. 
Targeting the mTOR Network to Maximize Healthspan

  • Mechanisms of Neuroprotection by mTOR Inhibitors, Veronica Galvan
  • Sex and Tissue Specific Roles of mTORC2 in Healthspan, Metabolism and Survival, Dudley Lamming
  • Anti-Cell Senescent Effects of Rapamycin and Their Role in Diseases, Including Alzheimer's, Viviana Perez
  • Low Translation downstream of TOR Activates Myogene Expression and Enhances Health of Body Muscle in C. elegans, Juyoung K. Shim, Santina Snow, Amber Howard, Jordan Horrocks, Joshua Kelley

Friday, November 15

8 to 9:30 a.m.
Is Aging an Acquired Mitochondrial Disease?

  • Turning the Oxygen Dial as a Therapy: Hypoxia Treatment for Mitochondrial Dysfunction, Isha Jain
  • Aging and Mitochondrial Disease: Shared Mechanisms and Therapies?, Alessandro Bitto, Herman Tung, Kejun Ying, Daniel L. Smith, Ernst-Bernhard Kayser, Philip G. Morgan, Margaret M. Sedensky, Matt Kaeberlein
  • Mitochondria as Reversible Regulators of Aging Associated Skin Wrinkles and Hair Loss in Mice, Keshav Singh
  • Does augmentation of mitochondrial thioredoxin reductase 2 improve metabolic fitness?, Sandra Chocron

10 to 11:30 a.m.
ESPO/ Biological Sciences Section Symposium: Emerging Insights in Interactions and Networks in the Biology of Aging
Chair:
Matt Kaeberlein, Jessica Hoffman

  • Epigenetic Profiles of Biological Aging Hallmarks, Diana L. Leung, Zuyun Liu, Morgan E. Levine
  • The Effects of Age and Size on the Companion Dog Metabolome: Roles of Tryptophan and Fatty Acid Metabolism, Jessica Hoffman, Steven Austad
  • Cardiac Antioxidant Response to Air Pollution in Mice Is Altered by ApoE Alleles and Sex, Max Thorwald, Mafalda Cacciottolo, Todd E. Morgan, Caleb E. Finch
  • Developing C. Elegans to Study Age-related Extracellular Vesicle Signals, Joshua Russell, Matt Kaeberlein

12 to 1:30 p.m.
BS Section Business Meeting and Award Presentation
separate registration required

5 to 8 p.m.
Irving S. Wright and Vincent Cristofalo “Rising Star” Award Presentation, Lecture, and Reception

These awards are given by American Federation for Aging Research (AFAR) Inc.

Saturday, November 16

8 to 9:30 a.m.
Mechanisms of Cognitive and Neurological Aging

  • Mechanisms of Brain Rejuvenation, Saul Villeda
  • Jump Around Jump Around: Transposable Element Activation in Neurodegenerative Taupathy, Bess Frost, Wenyan Sun, Hanie Samimi
  • Multi-Omics Analysis Identifies Gene Networks Associated With Cognitive Aging and Alzheimer's Disease, Catherine Kaczorowski, Sarah Heuer
  • Assessing Brain Volumetrics in the Aging Brain using Computed Tomography, Andrei Irimia, Alexander Maher, Kenneth Rostowsky

10 to 10:30 a.m.
GSA Business Meeting and Installation of 2020 GSA President

10:30 to 11:45 a.m.
Kent and Kleemeier Award Lectures 

12 to 1:30 pm
Intervening in the Longevity Network

  • Targeting Tryptophan-Kynurenine Metabolism to Extend Lifespan and Treat Age-Associated Disease, George Sutphin
  • Increased Lifespan Through Altered Gcn4/ ATF-5 in S. Cerevisiae and C. Elegans, Mark McCormick, Christine Robbins, Olivia Heath, Marissa Westenskow
  • Leveraging Drug-Drug Interactions for Pharmacological Extension of Healthy Lifespan, Jan Gruber
  • Understanding Aging in Terms of Physiological States, Alex Mendenhall, Nikolay Burnaevskiy, Soo Yun

3:30 to 5 p.m.
Cell Non-Autonomous Mechanisms of Aging

  • Cell Non-Autonomous Serotonin Signaling Mediates Stress Resistance and Longevity, Scott Leiser, Hillary Miller, Shijiao Huang
  • Neuronal FGF-21 Signaling: A Sensor of Dietary Protein, Cristal Hill, Christopher Morrison
  • Increase in HSP25 Extends Lifespan and Improves Response to Tau Toxcitiy Through a Call, Non-Autonomous Mechanism, Karl Rodriguez
  • Restoration of Hypoxia Signaling Improves Aging-Associated Loss of Skeletal Muscle Regenerative Potential, Kodi Udeh, Bin Li, Yori Endo, Adriana Panayi, Dharaniya Sakthivel, Ron Neppl, Amy Wagers, Idranil Sinha

5:30 to 7 p.m.
Immunity and Aging - The Human Face

  • Dynamics of Human Mucosal-Associated Invariant T Cell Repertoires Across the Human Life-Span, Liyen Loh, Martha Lappas, Jane Crowe, Paul G. Thomas, Sidonia Eckle, Dale I. Godfrey, Katherine Kedzierska, Jeremy C. Crawford
  • Aged Induces an Emergence From Melanoma Dormancy, Mitchell Fane
  • Sex-Dimorphism in the Genomic Regulation of Aging, Berenice Benayoun, Ryan A. Lu; Nirmal K. Sampathkumar
  • A Longevity Promoting Factor that Suppresses Immunity and Healthspan, Arjumand Ghazi

Sunday, November 17

9 to 11:30 a.m.
Clinical Trials in Geroscience

  • Cellular Senecence as a Therapeutic Target for Geroscience-Guided Clinical Trials, Jamie Justice, Anoop M. Nambiar, Tamar Tchkonia, Nathan K. LeBrasseur, Nicolas Musi, Stephen B. Kritchevsky, James L. Kirkland
  • TORC1 Inhibition as an Immunotherapy to Decrease Infections in the Elderly, Joan Mannick
  • Aging Interventions Get Human - Can We Extend Healthspan?, Brian Kennedy

10:30 to 11:30 a.m.
The Gut Microbiome and Aging

  • Therapeutic Delivery of Ang(1-7) via Genetically Modified Probiotic: A Dosing Study, Christy S. Carter
  • The Influence of Life-Extending Mutation and Dietary Intervention on Gut Microbiota, Michal Masternak, Denise Wiesenborn, Augusto Schneider, Till Strowig, Karl Herbert Schafer, Eric Galvez
  • Nonhuman Primate Gut Microbiome: Impact of Age and Calorie Restriction, Ricki Colman, Federico Rey